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Phenotypes Associated with This Genotype
Genotype
MGI:4437606
Allelic
Composition		 Ext1tm1Vcs/Ext1+
Tg(Col2a1-rtTA,tetO-cre)22Pjro/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Vcs mutation (1 available); any Ext1 mutation (63 available)
Tg(Col2a1-rtTA,tetO-cre)22Pjro mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:157599 )
• with doxycycline induction of cre activity during gestation, only 1 pup was observed
• without doxycycline induction during gestation, viable offspring are generated

neoplasm
neoplasm ( J:157599 )
N
• mice exhibit no osteochondromas at 6-10 weeks of age with doxycycline induction from P8 to 15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory