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Phenotypes Associated with This Genotype
Genotype
MGI:4437568
Allelic
Composition
Mid1tm1Mero/Y
Genetic
Background
B6.Cg-Mid1tm1Mero
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mid1tm1Mero mutation (0 available); any Mid1 mutation (180 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• more rostral boundary between the inferior colliculus and the cerebellum at E17.5
• upturning of the external granule layer in the most anterior part of the anterobasal cardinal lobe
• premature halt of the anterior EGL
• slightly enlarged isthmic region at E17.5
• more anterior position of dorsal boundary
• Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum
• shorter with the difference in size more pronounced in lateral sections of the vermis at E14.5
• Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum
• more profound fissure delimiting future lobes II and III
• anterobasal cardinal lobe, appears abnormal at P0 and P2
• hypoplasia and abnormalities with a certain degree of variability
• hypoplasia and abnormalities with a certain degree of variability and abnormality in shape

behavior/neurological
• the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice
• record fewer correct responses in the egocentric spatial version of the cross maze task on the fourth training day
• however, performance in an allocentric version of the maze is not significantly different from controls
• delay in learning in a rotarod assay
• the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice
• impaired ability to hang on a wire
• make more false steps walking on an inclined wire

muscle
N
• no defects in muscle function are detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Opitz Gbbb Syndrome, Type I; GBBB1 300000 J:157828


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory