Mouse Genome Informatics
ot
    Mid1tm1Mero/Y
B6.Cg-Mid1tm1Mero
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• more rostral boundary between the inferior colliculus and the cerebellum at E17.5
• upturning of the external granule layer in the most anterior part of the anterobasal cardinal lobe
• premature halt of the anterior EGL
• slightly enlarged isthmic region at E17.5
• more anterior position of dorsal boundary
• Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum
• shorter with the difference in size more pronounced in lateral sections of the vermis at E14.5
• Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum
• more profound fissure delimiting future lobes II and III
• anterobasal cardinal lobe, appears abnormal at P0 and P2
• hypoplasia and abnormalities with a certain degree of variability
• hypoplasia and abnormalities with a certain degree of variability and abnormality in shape

behavior/neurological
• the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice
• record fewer correct responses in the egocentric spatial version of the cross maze task on the fourth training day
• however, performance in an allocentric version of the maze is not significantly different from controls
• delay in learning in a rotarod assay
• the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice
• impaired ability to hang on a wire
• make more false steps walking on an inclined wire

muscle
N
• no defects in muscle function are detected

Mouse Models of Human Disease
OMIM IDRef(s)
Opitz Gbbb Syndrome, Type I; GBBB1 300000 J:157828