Mouse Genome Informatics
ot
    Mid1tm1Mero/Y
B6.Cg-Mid1tm1Mero
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• more rostral boundary between the inferior colliculus and the cerebellum at E17.5 (J:157828)
• upturning of the external granule layer in the most anterior part of the anterobasal cardinal lobe (J:157828)
• premature halt of the anterior EGL (J:157828)
• slightly enlarged isthmic region at E17.5 (J:157828)
• more anterior position of dorsal boundary (J:157828)
• Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum (J:157828)
• shorter with the difference in size more pronounced in lateral sections of the vermis at E14.5 (J:157828)
• Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum (J:157828)
• more profound fissure delimiting future lobes II and III (J:157828)
• anterobasal cardinal lobe, appears abnormal at P0 and P2 (J:157828)
• totally missing (J:157828)
• hypoplasia and abnormalities with a certain degree of variability (J:157828)
• hypoplasia and abnormalities with a certain degree of variability and abnormality in shape (J:157828)

behavior/neurological
• however, performance in an allocentric version of the maze is not significantly different from controls (J:157828)
• the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice (J:157828)
• record fewer correct responses in the egocentric spatial version of the cross maze task on the fourth training day (J:157828)
• delay in learning in a rotarod assay (J:157828)
• the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice (J:157828)
• impaired ability to hang on a wire (J:157828)
• make more false steps walking on an inclined wire (J:157828)
(J:157828)

muscle
N
• no defects in muscle function are detected (J:157828)

Mouse Models of Human Disease
OMIM IDRef(s)
Opitz Gbbb Syndrome, X-Linked 300000 J:157828