Phenotypes Associated with This Genotype

Genotype
MGI:4437435

• Allelic Composition: Tg(Lrrk2)6Yue/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:157931 )

N • mice exhibit normal neuronal survival

tau protein deposits ( J:157931 )

• mice exhibit fewer tau deposits than wild-type mice or Tg(Lrrk2*G2019S)2Yue mice

increased neurotransmitter release ( J:157931 )

• at 12 months, evoked dopamine release is 25% higher than in wild-type mice

• however, dopamine uptake is normal

behavior/neurological

enhanced coordination ( J:157931 )

• compared with wild-type mice and Tg(Lrrk2*G2019S)2Yue mice

long stride length ( J:157931 )

• at 12 months, mice exhibit longer strides and greater diagonal distance between front and hind limbs than Tg(Lrrk2*G2019S)2Yue mice

• however, stride length and diagonal distance are the same as in wild-type mice

increased vertical activity ( J:157931 )

• in an open field test

increased locomotor activity ( J:157931 )

• in an open field test, mice exhibit an increased number of rearings, movement, and distance traveled compared with wild-type mice