Phenotypes Associated with This Genotype

Genotype
MGI:4437426

• Allelic Composition: Nodal^tm1Rob/Nodal⁺; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺; Tgif1^tm1Caw/Tgif1^tm1Caw; Tgif2^tm1Dwot/Tgif2^tm1Dwot
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:183402 )

• reduced Nodal levels partially rescues ventral neurepithelium morphogenesis observed in double mutants with disorganized neuroepithelium

abnormal forebrain development ( J:183402 )

• reduced Nodal levels partially rescues ventral forebrain morphology observed in double mutants with less disorganization and larger size

• however, forebrain cell proliferation is restored

holoprosencephaly ( J:183402 )

• in mice that survive to E18.5

decreased forebrain size ( J:183402 )

• in two-thirds of mice

embryo

abnormal left-right axis patterning ( J:157256 )

• expression analysis suggests there are some mild defects in left right patterning

rostral body truncation ( J:183402 )

• severe anterior truncation in a small proportion of mice

embryonic growth retardation ( J:183402 )

• in 2 embryos with severe anterior truncation

abnormal embryonic neuroepithelium morphology ( J:183402 )

• reduced Nodal levels partially rescues ventral neurepithelium morphogenesis observed in double mutants with disorganized neuroepithelium

growth/size/body

embryonic growth retardation ( J:183402 )

• in 2 embryos with severe anterior truncation

cardiovascular system

cardiovascular system phenotype ( J:157256 )

N • unlike in double null mice wild-type for Nodal, heart looping morphogenesis is normal