Analysis Tools
mortality/aging
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• unlike null homozygotes, rare mice do survive into adulthood
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• few mice survive past E16.5
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• some mice die between E11.5 and E14.5
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reproductive system
| N |
• rare mice that do survive into adulthood are fertile
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cardiovascular system
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• at E13.5, superficial vasculature is abnormal compared with wild-type mice
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• at E14.5
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• at E14.5, mice exhibit altered and retarded heart development compared with wild-type mice
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hemorrhage
(
J:157804
)
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• at E13.5, mice exhibit hemorrhagic livers and multiple body hemorrhages unlike wild-type mice
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• at E13.5
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embryo
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• at E14.5
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• at E13.5
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• at E13.5
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growth/size/body
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• at E13.5
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• at E13.5
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cellular
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• fibroblasts on polylysine or fibronectin exhibit delayed spreading compared with wild-type cells
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• in mouse embryonic fibroblasts
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homeostasis/metabolism
limbs/digits/tail
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• at E14.5, mice exhibit altered and retarded limb development compared with wild-type mice
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liver/biliary system
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• at E13.5
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• at E14.5, mice exhibit altered and retarded liver development compared with wild-type mice
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respiratory system
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• at E14.5, mice exhibit altered and retarded lung development compared with wild-type mice
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