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Phenotypes Associated with This Genotype
Genotype
MGI:4437297
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (14 available)
Smad1tm2Rob mutation (0 available); any Smad1 mutation (25 available)
Smad5tm1Huy mutation (0 available); any Smad5 mutation (6 available)
Smad5tm1Zuk mutation (1 available); any Smad5 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary

endocrine/exocrine glands
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary

mortality/aging
• 33% of mutant females survived to 32 weeks
• 50% survival at approximately 29 week of age

neoplasm
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:157310


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory