Mouse Genome Informatics
cn
    Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2.1Rob
Smad5tm1Huy/Smad5tm1Huy

involves: 129S5/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 33% of mutant females survived to 32 weeks
• 50% survival at approximately 29 week of age

tumorigenesis
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age) (J:157310)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level (J:157310)
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary (J:157310)

homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:157310