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Phenotypes Associated with This Genotype
Genotype
MGI:4437265
Allelic
Composition
Runx1tm1.1Gss/Runx1tm1.1Gss
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1.1Gss mutation (0 available); any Runx1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at E12.5 from central nervous system hemorrhage

hematopoietic system
• E12.5 liver cells fail to form colonies in a methocellulose colony forming unit assay unlike wild-type cells
• at E12.5, livers lack hematopoietic precursor/progenitor cells unlike in wild-type mice

liver/biliary system
• at E12.5

cardiovascular system
• at E12.5, mice exhibit variable patterns of hemorrhage including in the central nervous system unlike wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory