About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4437233
Allelic
Composition		 Chrm1tm2.1Stl/Chrm1tm2.1Stl
Tg(Grik4-cre)G32-4Stl/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1tm2.1Stl mutation (0 available); any Chrm1 mutation (27 available)
Tg(Grik4-cre)G32-4Stl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic currents ( J:156540 )
• excitatory postsynaptic currents from hippocampal slices are higher than in wild-type
abnormal long-term depression ( J:156540 )
• (S)-3,5-dihydroxyphenylglycine hydrate (DHPG), an mGluR agonist, fails to produce long-term depression in hippocampal slices
• pretreatment of hippocampal slices with PKC activator 12-O-tetradecanoylphorbol 13-acetate, restores DHPG long-term

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory