Phenotypes Associated with This Genotype

Genotype
MGI:4437224

• Allelic Composition: Fgf8^tm2.1Jyhl/Fgf8^tm2.1Jyhl
• Genetic Background: involves: 129S6/SvEvTac * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:156717 )

• some pups are found dead before weaning

• Background Sensitivity: lethality is less severe on a CD-1 outbred background compared to a C57BL/6J inbred background

growth/size/body

decreased body weight ( J:156717 )

• average body weight is significantly lower at E18.5 and postnatal day 24

nervous system

nervous system phenotype ( J:156717 )

N • unlike in mice lacking all isoforms of Fgf8, midbrain and cerebellum formation are normal