Phenotypes for Nrxn2 Nrxn3 MGI:4437136 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Nrxn2^tm1Sud/Nrxn2^tm1Sud Nrxn3^tm1Sud/Nrxn3^tm1Sud
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrxn2^tm1Sud mutation (3 available); any Nrxn2 mutation (87 available)
Nrxn3^tm1Sud mutation (1 available); any Nrxn3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:89452 )

• about 40% survive to P30

postnatal lethality, incomplete penetrance ( J:89452 )

• about 60% survive to P10

nervous system

abnormal excitatory postsynaptic currents ( J:89452 )

• impaired evoked synaptic transmission in brainstem

respiratory system

abnormal breathing pattern ( J:89452 )

• respiration is abnormal with an irregular rhythm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23