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Phenotypes Associated with This Genotype
Genotype
MGI:4437129
Allelic
Composition		 Nr1h2tm1Dgen/Nr1h2tm1Dgen
Genetic
Background		 B6.129-Nr1h2tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h2tm1Dgen mutation (0 available); any Nr1h2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal skeleton physiology ( J:157551 )
• increased proteoglycan degradation following IL-1beta stimulation as reflected by the total amount of aggrecan released into the culture medium compared with cartilage explants from wild-type mice
• about 5 times higher prostaglandinE2(PGE2) production by mouse hip cartilage upon IL-1beta treatment compared with cartilage explants from wild-type mice
• no gross abnormalities of joints structure at 3 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory