Phenotypes Associated with This Genotype

Genotype
MGI:4437055

• Allelic Composition: Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:157098 )

N • injection of adenovirus expressing cre do not alter brain morphology, expression of midbrain dopamine neuron markers, or microglia activation

decreased dopaminergic neuron number ( J:157098 )

• mice injected with an adenovirus expressing cre exhibit a progressive decrease in dopaminergic neurons compared with wild-type mice

behavior/neurological

akinesia ( J:157098 )

• 3 to 4 months after injection with an adenovirus expressing cre, mice exhibit impaired performance in a stepping test compared with wild-type mice

homeostasis/metabolism

decreased dopamine level ( J:157098 )

• in the dorsolateral striatum and areas innervated by scattered ventral tegmental area of mice injected with an adenovirus expressing cre