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Phenotypes Associated with This Genotype
Genotype
MGI:4436916
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (1060 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreas development ( J:86975 )
• sequential injection of tamoxifen to pregnant females at E13.5 and E14.5 to activate cre recombinase results in a pancreatic tubular epithelium devoid of endocrine and exocrine markers, indicating impaired differentiation of progenitor cells
• however, when tamoxifen is injected into adults, mature endocrine are not perturbed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory