Phenotypes Associated with This Genotype

Genotype
MGI:4436909

• Allelic Composition: Del(7Mrgpra1-Mrgprb4)1And/Del(7Mrgpra1-Mrgprb4)1And
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:157470 )

N • mice exhibit normal performance on a rotarod

impaired behavioral response to xenobiotic ( J:157470 )

• mice exhibit reduced chloroquine-induced scratching compared with similarly treated wild-type mice

• however, histaminergic itch is normal and over-expression of rat MrgprA restores normal chloroquine sensitivity

abnormal nociception after inflammation ( J:157470 )

• mice exhibit a modest increase in acute pain sensation at certain time points in inflammatory hyperalgesia induced by complete Freund's adjuvant or carrageenen injection compared with similarly treated wild-type mice

• however, mice exhibit normal response to acute noxious heat, cold, and mechanical stimulation, neuropathic pain caused by L5 spinal nerve ligation, and chemically-induced itch response

nervous system

nervous system phenotype ( J:157470 )

N • mice exhibit normal neuronal survival, fate determination, and differentiation of small-diameter sensory neurons

abnormal sensory neuron physiology ( J:157470 )

• dorsal root ganglion fail to respond to chloroquine treatment with increased calcium signaling unlike similarly treated wild-type cells

• dorsal root ganglion fail to respond to BAM8-22 unlike similarly treated wild-type cells

• however, histaminergic itch is normal and over-expression of rat MrgprA restores normal chloroquine sensitivity

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:157470 )

• dorsal root ganglion fail to respond to chloroquine treatment with increased calcium signaling unlike similarly treated wild-type cells

• dorsal root ganglion fail to respond to BAM8-22 unlike similarly treated wild-type cells

• however, over-expression of rat MrgprA restores normal chloroquine sensitivity