Phenotypes Associated with This Genotype

Genotype
MGI:4436873

• Allelic Composition: H2^dlAb1-Ea/H2^dlAb1-Ea
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:157516 )

N • stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha

abnormal T cell number ( J:57484 )

decreased CD4-positive, alpha-beta T cell number ( J:57484 )

• significantly decreased number of CD4+ thymocytes

• almost completely absent in spleen and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:57484 )

abnormal immunoglobulin level ( J:57484 )

decreased IgG1 level ( J:57484 )

decreased IgG2a level ( J:57484 )

increased IgM level ( J:57484 )

hematopoietic system

abnormal T cell number ( J:57484 )

decreased CD4-positive, alpha-beta T cell number ( J:57484 )

• significantly decreased number of CD4+ thymocytes

• almost completely absent in spleen and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:57484 )

abnormal immunoglobulin level ( J:57484 )

decreased IgG1 level ( J:57484 )

decreased IgG2a level ( J:57484 )

increased IgM level ( J:57484 )