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Phenotypes Associated with This Genotype
Genotype
MGI:4430871
Allelic
Composition		 Kitltm3.1Pbes/Kitltm3.1Pbes
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm3.1Pbes mutation (0 available); any Kitl mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
early reproductive senescence ( J:157170 )
• infertile after 8 weeks old

reproductive system
azoospermia ( J:157170 )
• absence of developing germ cells in the testis and mature sperm in the epididymis in adult mice
• multilayered seminiferous epithelia with mature sperm lining the lumen at 4 weeks
• gradual loss of germ cells starting at 4 weeks, resulting in empty tubules by 8 weeks
decreased testis weight ( J:157170 )
• 90% reduction compared to wild-type
early reproductive senescence ( J:157170 )
• infertile after 8 weeks old

pigmentation
absent coat pigmentation ( J:157170 )
• white with black eyes and residual pigmentation on ear tips and snout

hematopoietic system
decreased erythrocyte cell number ( J:157170 )
• slightly reduced red blood cell numbers
increased mean corpuscular volume ( J:157170 )
• marginally increased mean corpuscular volume
decreased mast cell number ( J:157170 )
• severely reduced mast cell numbers per centimeter skin compared to wild-type as assessed by toluidine blue staining
• reduced peritoneal mast cell numbers
decreased thymocyte number ( J:157170 )
• decreased thymus cellularity
• decreased Lin- thymocyte numbers
• normal bone marrow cellularity
decreased double-negative T cell number ( J:157170 )
• decreased CD44+CD25+, CD44-CD25+, and CD44-CD25- in CD3-/CD8-/CD4- thymocyte subsets
decreased double-positive T cell number ( J:157170 )
• decreased CD4+/CD8+ double positive cells
abnormal bone marrow cell physiology ( J:157170 )
• strongly impaired hematopoietic growth in long-term bone marrow cultures

endocrine/exocrine glands
decreased thymocyte number ( J:157170 )
• decreased thymus cellularity
• decreased Lin- thymocyte numbers
• normal bone marrow cellularity
decreased testis weight ( J:157170 )
• 90% reduction compared to wild-type

immune system
decreased mast cell number ( J:157170 )
• severely reduced mast cell numbers per centimeter skin compared to wild-type as assessed by toluidine blue staining
• reduced peritoneal mast cell numbers
decreased thymocyte number ( J:157170 )
• decreased thymus cellularity
• decreased Lin- thymocyte numbers
• normal bone marrow cellularity
decreased double-negative T cell number ( J:157170 )
• decreased CD44+CD25+, CD44-CD25+, and CD44-CD25- in CD3-/CD8-/CD4- thymocyte subsets
decreased double-positive T cell number ( J:157170 )
• decreased CD4+/CD8+ double positive cells

integument
absent coat pigmentation ( J:157170 )
• white with black eyes and residual pigmentation on ear tips and snout

cellular
azoospermia ( J:157170 )
• absence of developing germ cells in the testis and mature sperm in the epididymis in adult mice
• multilayered seminiferous epithelia with mature sperm lining the lumen at 4 weeks
• gradual loss of germ cells starting at 4 weeks, resulting in empty tubules by 8 weeks

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory