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Phenotypes Associated with This Genotype
Genotype
MGI:4430869
Allelic
Composition
Kitltm2.1Pbes/Kitltm2.1Pbes
Genetic
Background
involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Pbes mutation (0 available); any Kitl mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 50% reduction compared to wild-type
• normal spermatogenesis by histological analysis

cellular
• reduced BrdU incorporation in the adult testis
• distinct patches of PCNA-absent regions in the adult testis

hematopoietic system
• increased clonogenic mast cell progenitors
• increased mast cell numbers per centimeter skin compared to wild-type as assessed by toluidine blue staining
• increased peritoneal mast cell numbers

endocrine/exocrine glands
• 50% reduction compared to wild-type
• normal spermatogenesis by histological analysis

immune system
• increased mast cell numbers per centimeter skin compared to wild-type as assessed by toluidine blue staining
• increased peritoneal mast cell numbers


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory