Phenotypes Associated with This Genotype

Genotype
MGI:4430603

• Allelic Composition: plt/plt
• Genetic Background: B6.DDD-plt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:93960 )

N • no single positive T cell abnormalities other than the migration defect from cortex to medulla of the thymus

abnormal leukocyte migration ( J:93960 )

• single positive T cells fail to localize to the medulla of the thymus in newborns

• single positive T cells are retained in the cortex of the thymus

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

hematopoietic system

abnormal leukocyte migration ( J:93960 )

• single positive T cells fail to localize to the medulla of the thymus in newborns

• single positive T cells are retained in the cortex of the thymus

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

cellular

abnormal leukocyte migration ( J:93960 )

• single positive T cells fail to localize to the medulla of the thymus in newborns

• single positive T cells are retained in the cortex of the thymus

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls