Phenotypes Associated with This Genotype

Genotype
MGI:4430414

• Allelic Composition: Rad50^tm1Flv/Rad50^tm1Flv
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 physiology ( J:94870 )

• following immunization in vivo, splenocytes produce less TH2 cytokines (IL4, IL5, and IL13) compared with cells from similarly treated wild-type mice

decreased interleukin-13 secretion ( J:94870 )

• from splenocytes following immunization in vivo

decreased interleukin-4 secretion ( J:94870 )

• from splenocytes following immunization in vivo

decreased interleukin-5 secretion ( J:94870 )

• from splenocytes following immunization in vivo

hematopoietic system

abnormal T-helper 2 physiology ( J:94870 )

• following immunization in vivo, splenocytes produce less TH2 cytokines (IL4, IL5, and IL13) compared with cells from similarly treated wild-type mice