Phenotypes Associated with This Genotype

Genotype
MGI:4430401

• Allelic Composition: Tg(Myh6-Gnaq)#Gwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:145086 )

• postpartum, 50% of mice die of heart failure unlike wild-type mice

• however, neonatal survival is normal

cardiovascular system

enlarged heart ( J:145086 )

• postpartum

abnormal heart ventricle morphology ( J:145086 )

• mice exhibit mild ventricular remodeling as measured by the ratio of the ventricular radius to wall thickness unlike in wild-type mice

abnormal heart left ventricle morphology ( J:145086 )

• postpartum, mice exhibit left ventricle remodeling unlike wild-type mice

dilated heart ( J:145086 )

• postpartum

decreased cardiac muscle contractility ( J:145086 )

• postpartum, fractional shortening is decreased 50% compared to in wild-type mice

congestive heart failure ( J:145086 )

• postpartum, 50% of mice die of heart failure unlike wild-type mice

muscle

decreased cardiac muscle contractility ( J:145086 )

• postpartum, fractional shortening is decreased 50% compared to in wild-type mice

increased cardiomyocyte apoptosis ( J:145086 )

• postpartum but not neonatally

cellular

increased cardiomyocyte apoptosis ( J:145086 )

• postpartum but not neonatally

growth/size/body

enlarged heart ( J:145086 )

• postpartum