Phenotypes Associated with This Genotype

Genotype
MGI:4430376

• Allelic Composition: Igf1^tm1Dlr/Igf1^tm1Dlr; Tg(Alb1-cre)1Dlr/0
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:155733 )

• male mutant LID (LID, chronic liver-specific IGF-1 deficiency) mice fed a high calorie or regular diet for 8 to 10 weeks exhibit decreased serum IGF-1 levels relative to controls

increased circulating leptin level ( J:155733 )

• LID mice fed a high calorie for 8 to 10 weeks exhibit increased serum leptin levels compared to lean LID mice (fed a regular diet)

neoplasm

decreased tumor growth/size ( J:155733 )

• male double mutant (LID, chronic liver-specific IGF-1 deficiency) mice on a high calorie diet for 10-14 weeks and injected with subcutaneous MC-39 murine colorectal carcinoma cell do not show the obesity-associated increase in local tumor growth compared to lean controls