Phenotypes Associated with This Genotype

Genotype
MGI:4430335

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}; Tg(Gdf9-icre)5092Coo/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal female germ cell apoptosis ( J:157008 )

♀ • oocytes have undergone apoptosis in preantral follicles

abnormal granulosa cell apoptosis ( J:157008 )

♀ • granulosa cells have undergone apoptosis in preantral follicles

reproductive system

abnormal female germ cell apoptosis ( J:157008 )

♀ • oocytes have undergone apoptosis in preantral follicles

abnormal granulosa cell apoptosis ( J:157008 )

♀ • granulosa cells have undergone apoptosis in preantral follicles

abnormal ovary morphology ( J:157008 )

♀

abnormal ovarian follicle morphology ( J:157008 )

♀ • with diptheria toxin administration to 8-week-old pregnant females, oocytes and granulosa cells in preantral oocytes show apoptosis 9 days later, in contrast to treated controls where atretic follicles but not preantral follicles show apoptosis

endocrine/exocrine glands

abnormal granulosa cell apoptosis ( J:157008 )

♀ • granulosa cells have undergone apoptosis in preantral follicles

abnormal ovary morphology ( J:157008 )

♀

abnormal ovarian follicle morphology ( J:157008 )

♀ • with diptheria toxin administration to 8-week-old pregnant females, oocytes and granulosa cells in preantral oocytes show apoptosis 9 days later, in contrast to treated controls where atretic follicles but not preantral follicles show apoptosis