Phenotypes Associated with This Genotype

Genotype
MGI:4430333

• Allelic Composition: Foxl2^tm2.1Tre/Foxl2^tm2.1Tre; Tg(Cga-cre)3Sac/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal ovary morphology ( J:157008 )

• almost entire structure is affected

• instead of normal granulosa cells, cells with morphological characteristics of Sertoli cells (prominent basal lamina, tripartite nuclei, numerous veil-like cytoplasmic extensions pointing toward lumen) are observed

abnormal ovarian follicle morphology ( J:157008 )

• typical follicular structure of ovary resembles seminiferous tubules of testis

abnormal ovary size ( J:157008 )

• size is increased compared to control females

primary sex reversal ( J:157008 )

• female mice exhibit gonadal sex reversal

endocrine/exocrine glands

abnormal ovary morphology ( J:157008 )

• almost entire structure is affected

• instead of normal granulosa cells, cells with morphological characteristics of Sertoli cells (prominent basal lamina, tripartite nuclei, numerous veil-like cytoplasmic extensions pointing toward lumen) are observed

abnormal ovarian follicle morphology ( J:157008 )

• typical follicular structure of ovary resembles seminiferous tubules of testis

abnormal ovary size ( J:157008 )

• size is increased compared to control females