Analysis Tools
reproductive system
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• almost entire structure is affected by 3 weeks following tamoxifen treatment
• instead of normal granulosa cells, cells with morphological characteristics of Sertoli cells (prominent basal lamina, tripartite nuclei, numerous veil-like cytoplasmic extensions pointing toward lumen) are observed 3 weeks following tamoxifen treatment; Leydig cell markers are also detected in mutant gonads
• one week after start of tamoxifen treatment, many granulosa cells start to transdifferentiate into Sertoli-like cells; unlike normal granulosa cells, these abnormal cells do not undergo apoptosis at end of a follicle life cycle and are still present after 6 months
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• 3 weeks following tamoxifen treatment, typical follicular structure of ovary resembles seminiferous tubules of testis
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• 8-week-old female mice treated for 5 days with tamoxifen and analysed 3 weeks later exhibit gonadal sex reversal
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endocrine/exocrine glands
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• almost entire structure is affected by 3 weeks following tamoxifen treatment
• instead of normal granulosa cells, cells with morphological characteristics of Sertoli cells (prominent basal lamina, tripartite nuclei, numerous veil-like cytoplasmic extensions pointing toward lumen) are observed 3 weeks following tamoxifen treatment; Leydig cell markers are also detected in mutant gonads
• one week after start of tamoxifen treatment, many granulosa cells start to transdifferentiate into Sertoli-like cells; unlike normal granulosa cells, these abnormal cells do not undergo apoptosis at end of a follicle life cycle and are still present after 6 months
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• 3 weeks following tamoxifen treatment, typical follicular structure of ovary resembles seminiferous tubules of testis
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