Phenotypes Associated with This Genotype

Genotype
MGI:4430235

• Allelic Composition: Foxp3^tm7.2Ayr/Foxp3^tm7.2Ayr
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal regulatory T cell morphology ( J:156942 )

♀ • numbers of proliferating Ki67+ Foxp3+ thymocytes and peripheral cells are increased compared to control

decreased regulatory T cell number ( J:156942 )

♀ • about a 5-fold decrease in the frequency of Foxp3+ CD4 single-positive thymocytes but the amount of Foxp3 on a per cell basis is unaffected

♀ • in spleen and thymus peripheral Treg cell frequencies are moderately diminished

immune system

abnormal regulatory T cell morphology ( J:156942 )

♀ • numbers of proliferating Ki67+ Foxp3+ thymocytes and peripheral cells are increased compared to control

decreased regulatory T cell number ( J:156942 )

♀ • about a 5-fold decrease in the frequency of Foxp3+ CD4 single-positive thymocytes but the amount of Foxp3 on a per cell basis is unaffected

♀ • in spleen and thymus peripheral Treg cell frequencies are moderately diminished