About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4430105
Allelic
Composition
Tg(Rho-GUCA1A*Y99C)L53Amd/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• by 6 months of age, both rods and cones are absent (J:157063)
• by 6 months of age, both rods and cones are absent (J:157063)
• as early as 3 weeks of age (J:157063)
• as early as 3 weeks of age (J:157063)
• by 6 months of age only a few photoreceptor nuclei remaining (J:157063)
• by 6 months of age only a few photoreceptor nuclei remaining (J:157063)
• calcium sensitivity of guanylyl cyclase in photoreceptors is shifted compared to in wild-type photoreceptors (J:157063)
• in darkness, rod outer segment calcium levels are higher than in wild-type cells (J:157063)
• calcium sensitivity of guanylyl cyclase in photoreceptors is shifted compared to in wild-type photoreceptors (J:157063)
• in darkness, rod outer segment calcium levels are higher than in wild-type cells (J:157063)
• at 6 months, cone-driven b-wave is suppressed compared to in wild-type mice (J:157063)
• at 6 months, cone-driven b-wave is suppressed compared to in wild-type mice (J:157063)
• at 5 to 7 months, the dark-adapted corneal negative a-wave is absent unlike in wild-type mice (J:157063)
• the average singe photon response is 1.8-fold larger and peaks later than in similarly treated wild-type rods (J:157063)
• at 5 to 7 months, the dark-adapted corneal negative a-wave is absent unlike in wild-type mice (J:157063)
• the average singe photon response is 1.8-fold larger and peaks later than in similarly treated wild-type rods (J:157063)

nervous system
• by 6 months of age, both rods and cones are absent (J:157063)
• by 6 months of age, both rods and cones are absent (J:157063)
• as early as 3 weeks of age (J:157063)
• as early as 3 weeks of age (J:157063)
• by 6 months of age only a few photoreceptor nuclei remaining (J:157063)
• by 6 months of age only a few photoreceptor nuclei remaining (J:157063)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cone Dystrophy 3; COD3 602093 J:157063


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory