Phenotypes Associated with This Genotype

Genotype
MGI:4429668

• Allelic Composition: Drd2^tm1Low/Drd2⁺
• Genetic Background: B6.129S2-Drd2^tm1Low

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:50787 )

N • mice exhibit a normal saccharin and quinine preference and locomotor depressant response to SCH-23390 treatment

impaired behavioral response to alcohol ( J:50787 )

• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice

abnormal locomotor behavior ( J:47001 )

• mice exhibit decreased horizontal distance and rearing compared with C57BL/6 mice

ataxia ( J:50787 )

• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice

decreased vertical activity ( J:47001 )

decreased locomotor activity ( J:50787 )

cardiovascular system

abnormal systemic arterial blood pressure ( J:103181 )

• mice exhibit increased blood pressure compared with wild-type mice

• however, acute adrenalectomy results in normal blood pressure compared with similarly treated wild-type mice

increased mean systemic arterial blood pressure ( J:103181 )

increased systemic arterial diastolic blood pressure ( J:103181 )

increased systemic arterial systolic blood pressure ( J:103181 )

growth/size/body

increased body weight ( J:103181 )

• compared with wild-type mice or homozygotes