Phenotypes Associated with This Genotype

Genotype
MGI:4429665

• Allelic Composition: Drd2^tm1Low/Drd2^tm1Low
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:47001 )

• mice exhibit abnormal motor function with reduced horizontal distance, initiation of movement, time in motion, and number of rearing events compared with C57BL/6 mice

• unlike in wild-type mice, locomotor parameters are unaffected by treatment with haloperidol

• reserpine and AMPT-treated mice are slightly more active than C57BL/6 mice

• locomotor parameters are unaffected by treatment with SKF38393 and quinpirole unlike in wild-type mice

abnormal locomotor activation ( J:47001 )

• mice exhibit reduced initiation of movement compared with 129S/SvEv or C57BL/6 mice

decreased vertical activity ( J:47001 )

• compared with C57BL/6 mice but not 129S/SvEv mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:47001 )

• unlike in wild-type mice, locomotor parameters are unaffected by treatment with haloperidol

• reserpine and AMPT-treated mice are slightly more active than similarly treated C57BL/6 mice

• locomotor parameters are unaffected by treatment with SKF38393 and quinpirole unlike similarly treated wild-type mice