Phenotypes Associated with This Genotype

Genotype
MGI:4429660

• Allelic Composition: Drd2^tm1Low/Drd2^tm1Low
• Genetic Background: either: B6.129S2-Drd2^tm1Low or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

uterus cyst ( J:41858 )

♀ • in aged female mice

short uterine horn ( J:41858 )

♀ • shorter and thicker than in wild-type mice

uterus hyperplasia ( J:41858 )

♀ • in aged female mice

uterus adenomyosis ( J:41858 )

♀ • in 9 of 16 aged female mice

nervous system

abnormal pituitary gland morphology ( J:41858 )

• pituitary glands exhibit enlarged glandular acini unlike in wild-type mice

• however, pituitary intermediate lobe size is normal

abnormal adenohypophysis morphology ( J:41858 )

• older female mice exhibit diffusely enlarged, hyperemic anterior pituitary lobes without focal nodules

adenohypophysis peliosis ( J:41858 )

• mice exhibit peliosis unlike wild-type mice

decreased gonadotroph cell number ( J:41858 )

• fewer gonadotrophs stain positive for beta-follicle stimulating hormone and beta-luteinizing hormone compared to in wild-type mice

increased lactotroph cell number ( J:41858 )

adenohypophysis hyperplasia ( J:41858 )

adenohypophysis hypertrophy ( J:41858 )

enlarged pituitary gland ( J:41858 )

• in the anterior lobe due to hyperplasia and hypertrophy with prominent vascular spaces

increased pituitary gland weight ( J:41858 )

• 4- to 10-fold

homeostasis/metabolism

increased circulating prolactin level ( J:41858 )

• mice exhibit a 3-fold increase in circulating prolactin levels compared with wild-type mice that is insensitive to treatment with the dopamine receptor 2 antagonist haloperidol

• ages female mice exhibit an age-dependent increase in circulating prolactin levels unlike male mice

decreased physiological sensitivity to xenobiotic ( J:41858 )

• mice exhibit a 3-fold increase in circulating prolactin levels compared with wild-type mice that is insensitive to treatment with the dopamine receptor 2 antagonist haloperidol

endocrine/exocrine glands

abnormal pituitary gland morphology ( J:41858 )

• pituitary glands exhibit enlarged glandular acini unlike in wild-type mice

• however, pituitary intermediate lobe size is normal

abnormal adenohypophysis morphology ( J:41858 )

• older female mice exhibit diffusely enlarged, hyperemic anterior pituitary lobes without focal nodules

adenohypophysis peliosis ( J:41858 )

• mice exhibit peliosis unlike wild-type mice

decreased gonadotroph cell number ( J:41858 )

• fewer gonadotrophs stain positive for beta-follicle stimulating hormone and beta-luteinizing hormone compared to in wild-type mice

increased lactotroph cell number ( J:41858 )

adenohypophysis hyperplasia ( J:41858 )

adenohypophysis hypertrophy ( J:41858 )

enlarged pituitary gland ( J:41858 )

• in the anterior lobe due to hyperplasia and hypertrophy with prominent vascular spaces

increased pituitary gland weight ( J:41858 )

• 4- to 10-fold

cardiovascular system

adenohypophysis peliosis ( J:41858 )

• mice exhibit peliosis unlike wild-type mice

growth/size/body

uterus cyst ( J:41858 )

♀ • in aged female mice