Phenotypes Associated with This Genotype

Genotype
MGI:4429477

• Allelic Composition: Tg(Ckm-Ppard)MEDpk/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:129848 )

• in a glucose tolerance test, glucose excursion is greater than in wild-type mice

• when fed a high fat diet, mice exhibit greater glucose intolerance compared with similarly treated wild-type mice

insulin resistance ( J:129848 )

• when fed a high fat or standard diet

muscle

abnormal muscle cell glucose uptake ( J:129848 )

• insulin-stimulated glucose uptake is reduced compared to in wild-type mice

cellular

abnormal muscle cell glucose uptake ( J:129848 )

• insulin-stimulated glucose uptake is reduced compared to in wild-type mice