Phenotypes Associated with This Genotype

Genotype
MGI:4429464

• Allelic Composition: Tg(Myh6-Ppara)404-4Dpk/0
• Genetic Background: involves: C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:110580 )

• exhibit neutral lipid droplet accumulation in cardiac myocytes after a short-term fast

• myocardial triacylglycerol levels are higher in fasted mutants than in controls, specifically long-chain fatty acid-containing triacylglycerol

• myocyte hypertrophy seen in 3-month old mutants

cardiac hypertrophy ( J:110580 )

• exhibit an increase in biventricular weight/body weight ratio

homeostasis/metabolism

abnormal lipid level ( J:110580 )

• exhibit neutral lipid droplet accumulation in cardiac myocytes after a short-term fast

increased fatty acids level ( J:110580 )

• myocardial triacylglycerol levels are higher in fasted mutants than in controls, specifically long-chain fatty acid-containing triacylglycerol

muscle

abnormal myocardial fiber morphology ( J:110580 )

• exhibit neutral lipid droplet accumulation in cardiac myocytes after a short-term fast

• myocardial triacylglycerol levels are higher in fasted mutants than in controls, specifically long-chain fatty acid-containing triacylglycerol

• myocyte hypertrophy seen in 3-month old mutants

growth/size/body

cardiac hypertrophy ( J:110580 )

• exhibit an increase in biventricular weight/body weight ratio