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Phenotypes Associated with This Genotype
Genotype
MGI:4429149
Allelic
Composition		 Ewsr1tm2(FLI1*)Sblee/Ewsr1+
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ewsr1tm2(FLI1*)Sblee mutation (0 available); any Ewsr1 mutation (92 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:156860 )
• after tamoxifen injection, within 4 to 6 days mice become moribund and die

cellular
increased fibroblast apoptosis ( J:156860 )
• 24 hours after tamoxifen application MEF cultures begin to die and caspase-3 activity increases
increased renal tubule apoptosis ( J:156860 )
• after tamoxifen injection, increase in TUNEL+ cells in epithelia

renal/urinary system
increased renal tubule apoptosis ( J:156860 )
• after tamoxifen injection, increase in TUNEL+ cells in epithelia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory