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Phenotypes Associated with This Genotype
Genotype
MGI:4429127
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0
Tg(tetO-Vegfa)90Ala/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (47 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
Tg(tetO-Vegfa)90Ala mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hemangioma incidence ( J:156474 )
• local bone and marrow tissue in doxycycline-treat mice are replaced with massively enlarged vascular structures (hemangiomas) unlike in wild-type mice

skeleton
skeleton phenotype ( J:156474 )
N
• doxycycline-treat mice exhibit normal bone density, osteoclastic bone remodeling, and bone degradation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory