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Phenotypes Associated with This Genotype
Genotype
MGI:4429126
Allelic
Composition		 Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Kdrtm1Wag/Kdrtm1Wag
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Vegfa*)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (956 available)
Kdrtm1Wag mutation (0 available); any Kdr mutation (72 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:156474 )
N
• mice do not exhibit severe long bone kyphosis unlike in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice
abnormal long bone diaphysis morphology ( J:156474 )
• bone shafts in mice are wider than in wild-type mice
abnormal bone structure ( J:156474 )
• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice
increased bone mass ( J:156474 )
• mice exhibit an increase in mineralized bone formed compared with wild-type mice that is not as severe as in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice
abnormal skeleton development ( J:156474 )
• mesenchymal hyperproliferation in mice is reduced compared to in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice

cardiovascular system
abnormal blood vessel morphology ( J:156474 )
• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory