Phenotypes Associated with This Genotype

Genotype
MGI:4429123

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai}/Gt(ROSA)26Sor⁺; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156474 )

• mice die at birth

skeleton

abnormal long bone morphology ( J:156474 )

• long bones are abnormal and bent (kyphosis) compared to in wild-type mice

• however, skeletal patterning and growth is normal

abnormal long bone diaphysis morphology ( J:156474 )

• at E16.5, limb diaphyses are short and thick compared to in wild-type mice

• at E16.5, primary ossification centers are malformed compared to in wild-type mice

• at E16.5, ossification centers are laterally expanded with excessive, disorganized bone compared to in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:156474 )

• mild

abnormal rib morphology ( J:156474 )

• at E16.5, rib diaphyses are short and thick compared to in wild-type mice

abnormal bone structure ( J:156474 )

• at E16.5, limb and rib diaphyses are short and thick compared to in wild-type mice

• bone lack a proper cortex and abnormally oriented trabecular-like structures extend inside the bone, obliterating the developing marrow cavity unlike in wild-type mice

• mice exhibit increased blood vessels in the bone compared with wild-type mice

abnormal bone marrow cavity morphology ( J:156474 )

• abnormally oriented trabecular-like structures extend inside the bone, obliterating the developing marrow cavity unlike in wild-type mice

abnormal bone ossification ( J:156474 )

• at E16.5, primary ossification centers are malformed compared to in wild-type mice

• at E16.5, ossification centers are laterally expanded with excessive, disorganized bone compared to in wild-type mice