Phenotypes Associated with This Genotype

Genotype
MGI:4422181

• Allelic Composition: Stk3^tm1Yy/Stk3^tm1.1Yy; Stk4^tm1.1Yy/Stk4^tm1.1Yy; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb bone morphology ( J:156541 )

• shorter skeletal elements in the limbs

short limbs ( J:156541 )

skeleton

abnormal limb bone morphology ( J:156541 )

• shorter skeletal elements in the limbs

decreased length of long bones ( J:156541 )

abnormal cartilage morphology ( J:156541 )

• cell size appears smaller and cell density is increased in the limb cartilage

abnormal long bone hypertrophic chondrocyte zone ( J:156541 )

• proliferating cells are detected in the hypertrophic zone

• apoptosis is decreased compared to controls

• despite the increase in proliferation and decrease in apoptosis cartilage size is not increased

abnormal skeleton physiology ( J:156541 )

• increase in proliferation of cells in the developing limb