Phenotypes for Stk3 Stk4 MGI:4422180 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Stk3^tm1.1Yy/Stk3^tm1.1Yy Stk4^tm1.1Yy/Stk4^tm1.1Yy
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3^tm1.1Yy mutation (0 available); any Stk3 mutation (47 available)
Stk4^tm1.1Yy mutation (0 available); any Stk4 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:156541 )

• die between E9.5 and E11.5

embryo

abnormal embryo development ( J:156541 )

• multiple developmental defects at E9.5 - E10.5

embryonic growth retardation ( J:156541 )

• at E9.5-E10.5

cellular

decreased fibroblast apoptosis ( J:156541 )

• MEFs are resistant to TNF alpha induced apoptosis

decreased hepatocyte apoptosis ( J:156541 )

• resistant to TNF alpha induced apoptosis

liver/biliary system

decreased hepatocyte apoptosis ( J:156541 )

• resistant to TNF alpha induced apoptosis

growth/size/body

embryonic growth retardation ( J:156541 )

• at E9.5-E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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