Phenotypes for Cd74 Lmo2 Smim3 Trp53 MGI:4421779 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Anjm mutation (0 available); any Cd74 mutation (37 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (30 available)
Smim3^tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• a decrease in granulocyte/macrophage colony-forming units in bone marrow

• by flow cytometry, there is a reduction in granulocyte-monocyte progenitors in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• as measured by erythroid colony-forming units in bone marrow

decreased erythrocyte cell number ( J:155870 )

• a reduced number of circulating red blood cells

increased mean corpuscular volume ( J:155870 )

thrombocytopenia ( J:155870 )

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors in the bone marrow

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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