Phenotypes Associated with This Genotype

Genotype
MGI:4421707

• Allelic Composition: Grn^tm1.1Aidi/Grn^tm1.1Aidi
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exaggerated tissue inflammation in Grn^tm1.1Aidi/Grn^tm1.1Aidi mice after infection with L. monocytogenes

immune system

microgliosis ( J:156824 )

• mice exhibit increased age-dependent microgliosis compared with wild-type mice

abnormal macrophage physiology ( J:156824 )

• bone marrow-derived macrophages stimulated with Toll-like receptor agonist produce more MCP-1, CXCL1, IL6, IL12p40, and TNF compared with similarly treated wild-type cells

• activated bone marrow-derived macrophages exhibit increased killing potential compared with wild-type cells

abnormal microglial cell physiology ( J:156824 )

• GM-CSF and LPS/IFN-gamma treated mice exhibit increased cytotoxicity compared with similarly treated wild-type mice

abnormal chemokine secretion ( J:156824 )

• bone marrow-derived macrophages stimulated with Toll-like receptor agonist produce more MCP-1 and CXCL1 compared with similarly treated wild-type cells

increased interleukin-12 secretion ( J:156824 )

• IL12p40 production is increased in bone marrow-derived macrophages stimulated with Toll-like receptor agonist compared to in similarly treated wild-type cells

increased interleukin-6 secretion ( J:156824 )

• in bone marrow-derived macrophages stimulated with Toll-like receptor agonist

increased tumor necrosis factor secretion ( J:156824 )

• in bone marrow-derived macrophages stimulated with Toll-like receptor agonist

increased susceptibility to bacterial infection ( J:156824 )

• following infection with Listeria monocytogenes, mice exhibit fewer monocytes in the spleen and higher Listeria burden in the spleen, liver, and brain compared to in wild-type mice

nervous system

microgliosis ( J:156824 )

• mice exhibit increased age-dependent microgliosis compared with wild-type mice

abnormal microglial cell physiology ( J:156824 )

• GM-CSF and LPS/IFN-gamma treated mice exhibit increased cytotoxicity compared with similarly treated wild-type mice

astrocytosis ( J:156824 )

• mice exhibit increased age-dependent astrocytosis compared with wild-type mice

homeostasis/metabolism

increased susceptibility to injury ( J:156824 )

• hippocampal slices starved of glucose and oxygen exhibit increased cell death compared with similarly treated wild-type slices

hematopoietic system

microgliosis ( J:156824 )

• mice exhibit increased age-dependent microgliosis compared with wild-type mice

abnormal macrophage physiology ( J:156824 )

• bone marrow-derived macrophages stimulated with Toll-like receptor agonist produce more MCP-1, CXCL1, IL6, IL12p40, and TNF compared with similarly treated wild-type cells

• activated bone marrow-derived macrophages exhibit increased killing potential compared with wild-type cells

abnormal microglial cell physiology ( J:156824 )

• GM-CSF and LPS/IFN-gamma treated mice exhibit increased cytotoxicity compared with similarly treated wild-type mice