Phenotypes Associated with This Genotype

Genotype
MGI:4421539

• Allelic Composition: Abl1^tm1Goff/Abl1^tm1Goff; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:156743 )

• most die shortly after birth

cardiovascular system

cardiovascular system phenotype ( J:156743 )

N • compared to homozygous mutant mice not carrying the cre transgene, cardiomyocyte overproliferation and ventricular lumen size reduction are dramatically reduced

thick ventricular wall ( J:156743 )

• not as thick as in homozygous mutant mice not carrying the cre transgene but slightly thicker than in heterozygous controls