Phenotypes Associated with This Genotype

Genotype
MGI:4421509

• Allelic Composition: Bnc2^{Gt(pU21)18Imeg}/Bnc2^{Gt(pU21)18Imeg}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small head, cleft palate and tongue abnormalities in Bnc2^{Gt(pU21)18Imeg}/Bnc2^{Gt(pU21)18Imeg} mice

mortality/aging

neonatal lethality, complete penetrance ( J:151992 )

• mice die within 24 hours of birth

craniofacial

wide sagittal suture ( J:151992 )

• an excessively wide sagittal suture is clearly visible in newborns

large posterior fontanelle ( J:151992 )

• an abnormally large posterior fontanel is clearly visible in newborns

frontal bone hypoplasia ( J:151992 )

• diminished growth of the frontal bones

parietal bone hypoplasia ( J:151992 )

• diminished growth of the parietal bones

small alisphenoid bone ( J:151992 )

• the size of the alisphenoid is reduced

abnormal pterygoid process morphology ( J:151992 )

• the internal pterygoid processes have not extended caudally

abnormal maxillary shelf morphology ( J:151992 )

• fails to grow towards the midline and extend cranially unlike in wild-type mice

absent palatine bone ( J:151992 )

• the palatine bone is virtually absent in newborns

abnormal palate development ( J:151992 )

• at E14.5 and E16.5, the number of mesenchyme cells in metaphase, anaphase, or telophase in the palatal processes is decreased 50% compared to in wild-type mice

• however, the number of cells undergoing apoptosis is normal

palatal shelves fail to meet at midline ( J:151992 )

• at E16.5

cleft secondary palate ( J:151992 )

• 50% of mice exhibit a complete cleft secondary palate and the other 50% exhibit a posterior-only cleft secondary palate unlike in wild-type mice

decreased tongue size ( J:151992 )

• at E16.5 and P0

growth/size/body

abnormal maxillary shelf morphology ( J:151992 )

• fails to grow towards the midline and extend cranially unlike in wild-type mice

abnormal palate development ( J:151992 )

• at E14.5 and E16.5, the number of mesenchyme cells in metaphase, anaphase, or telophase in the palatal processes is decreased 50% compared to in wild-type mice

• however, the number of cells undergoing apoptosis is normal

palatal shelves fail to meet at midline ( J:151992 )

• at E16.5

cleft secondary palate ( J:151992 )

• 50% of mice exhibit a complete cleft secondary palate and the other 50% exhibit a posterior-only cleft secondary palate unlike in wild-type mice

decreased tongue size ( J:151992 )

• at E16.5 and P0

meteorism ( J:151992 )

• aerial distention of the digestive tract is observed at birth

decreased birth body size ( J:151992 )

microcephaly ( J:151992 )

• at E16.5, E18.5, and P0

skeleton

wide sagittal suture ( J:151992 )

• an excessively wide sagittal suture is clearly visible in newborns

large posterior fontanelle ( J:151992 )

• an abnormally large posterior fontanel is clearly visible in newborns

frontal bone hypoplasia ( J:151992 )

• diminished growth of the frontal bones

parietal bone hypoplasia ( J:151992 )

• diminished growth of the parietal bones

small alisphenoid bone ( J:151992 )

• the size of the alisphenoid is reduced

abnormal pterygoid process morphology ( J:151992 )

• the internal pterygoid processes have not extended caudally

abnormal maxillary shelf morphology ( J:151992 )

• fails to grow towards the midline and extend cranially unlike in wild-type mice

absent palatine bone ( J:151992 )

• the palatine bone is virtually absent in newborns

digestive/alimentary system

abnormal maxillary shelf morphology ( J:151992 )

• fails to grow towards the midline and extend cranially unlike in wild-type mice

abnormal palate development ( J:151992 )

• at E14.5 and E16.5, the number of mesenchyme cells in metaphase, anaphase, or telophase in the palatal processes is decreased 50% compared to in wild-type mice

• however, the number of cells undergoing apoptosis is normal

palatal shelves fail to meet at midline ( J:151992 )

• at E16.5

cleft secondary palate ( J:151992 )

• 50% of mice exhibit a complete cleft secondary palate and the other 50% exhibit a posterior-only cleft secondary palate unlike in wild-type mice

decreased tongue size ( J:151992 )

• at E16.5 and P0

meteorism ( J:151992 )

• aerial distention of the digestive tract is observed at birth