Phenotypes Associated with This Genotype

Genotype
MGI:4421500

• Allelic Composition: Ins2^Akita/Ins2^Akita
• Genetic Background: involves: C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal glucose and insulin homeostasis in Ins2^Akita/Ins2^Akita and Ins2^Akita/Ins2^Akita Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 but not Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice.

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:156725 )

• in 50% of mice at 8 weeks

abnormal pancreas physiology ( J:156725 )

• expression of a proliferation marker in the pancreas islet is decreased compared to in wild-type mice

increased pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is increased compared to in wild-type mice

decreased insulin secretion ( J:156725 )

• pancreas insulin levels are lower than in Cebpb^tm1.1Maka homozygotes

homeostasis/metabolism

decreased insulin secretion ( J:156725 )

• pancreas insulin levels are lower than in Cebpb^tm1.1Maka homozygotes

hyperglycemia ( J:156725 )

decreased circulating insulin level ( J:156725 )

cardiovascular system

hematoma ( J:168556 )

• greater hematoma expansion induced by autologous blood injection in diabetic mice

cellular

increased pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is increased compared to in wild-type mice