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Phenotypes Associated with This Genotype
Genotype
MGI:4421456
Allelic
Composition		 En1tm1Alj/En1tm8.1Alj
En2tm6Alj/En2+
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Alj mutation (2 available); any En1 mutation (34 available)
En1tm8.1Alj mutation (1 available); any En1 mutation (34 available)
En2tm6Alj mutation (1 available); any En2 mutation (105 available)
Gt(ROSA)26Sortm1(cre/ERT2)Alj mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased anterior vermis size ( J:156169 )
• when given tamoxifen at E10.5, at P21 the anterior region (lobules I-V) is reduced and the central region (lobules VI-VII) is preferentially expanded.
abnormal cerebellum vermis lobule morphology ( J:156169 )
• when tamoxifen is given at E10.5, at P21 lobule VIII extends more laterally than normal, as do lobules I-V but only on one side

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory