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Phenotypes Associated with This Genotype
Genotype
MGI:4421008
Allelic
Composition		 Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm1.1Cai mutation (1 available); any Lrrk2 mutation (156 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:156512 )
N
• no elevated reactive astrocytosis, neurodegeneration or somatic accumulation of alpha-synuclein is observed in brains of 20-month old mice compared to controls; no aggregates of alpha-synuclein form in mutant brains
microgliosis ( J:156512 )
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

immune system
microgliosis ( J:156512 )
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

hematopoietic system
microgliosis ( J:156512 )
• a moderate increase in microglial activation is observed in the brains of 20-month old animals

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory