Phenotypes Associated with This Genotype

Genotype
MGI:4421006

• Allelic Composition: Lrrk2^tm1.1Cai/Lrrk2⁺; Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-SNCA*A53T)E2Cai/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:156512 )

• somatic alpha synuclein in neurons is apparent at 12 months

astrocytosis ( J:156512 )

• significant at 12 months

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain at 12 months

abnormal striatum morphology ( J:156512 )

• numbers of residual neurons is significantly lower than non transgenic controls

abnormal neuron morphology ( J:156512 )

• the Golgi complex shows severe fragmentation in 12 month old animals

neurodegeneration ( J:156512 )

• neurodegeneration significant at 12 months

immune system

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain at 12 months

hematopoietic system

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain at 12 months

cellular

astrocytosis ( J:156512 )

• significant at 12 months

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain at 12 months