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Phenotypes Associated with This Genotype
Genotype
MGI:4421004
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)885Dbo/0
Tg(tetO-LRRK2*G2019S)E3Cai/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-APPSwInd)885Dbo mutation (2 available)
Tg(tetO-LRRK2*G2019S)E3Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neurodegeneration ( J:156512 )
• no acceleration of degeneration is observed compared to Tg(Camk2a-tTA)1Mmay/Tg(tetO-LRRK2*G2019S)E3Cai mice (G2019S)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory