Phenotypes Associated with This Genotype

Genotype
MGI:4420996

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-LRRK2)C77Cai/0; Tg(tetO-SNCA*A53T)E2Cai/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:156512 )

• increasing accumulation of alpha-synuclein is detected in cell bodies in brains of A53T/LRRK2WT-L at 1 month compared to LRRK2WT-L animals

astrocytosis ( J:156512 )

• A53T/LRRK2WT-L mice show significant elevation of GFAP-positive astrocytes in the striatum compared to A53T mice

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain

neurodegeneration ( J:156512 )

• neurodegeneration is accelerated in the striatum

abnormal nervous system physiology ( J:156512 )

• increasing accumulation of alpha-synuclein is detected in cell bodies at 1 month

behavior/neurological

abnormal locomotor behavior ( J:156512 )

• mice show no apparent motor phenotype up to 6 months of age

hematopoietic system

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain

immune system

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain

cellular

astrocytosis ( J:156512 )

• A53T/LRRK2WT-L mice show significant elevation of GFAP-positive astrocytes in the striatum compared to A53T mice

microgliosis ( J:156512 )

• increased microglial activation is observed in the brain