Phenotypes Associated with This Genotype

Genotype
MGI:4420986

• Allelic Composition: Ctsl^tm1Cptr/Ctsl⁺
• Genetic Background: NOD.129P2-Ctsl^tm1Cptr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:153355 )

• insulitis scores for diabetic animals are similar to diabetic NOD controls

decreased susceptibility to autoimmune diabetes ( J:153355 )

• 55% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age as compared to 69% of NOD controls

• adoptive transfer of GITR^hi-depleted Treg cells into NOD-Prkdc^scid host results in a diabetes incidence of 41.7%

homeostasis/metabolism

hyperglycemia ( J:153355 )

• 55% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age as compared to 69% of NOD controls

endocrine/exocrine glands

insulitis ( J:153355 )

• insulitis scores for diabetic animals are similar to diabetic NOD controls