Phenotypes Associated with This Genotype

Genotype
MGI:4420985

• Allelic Composition: Ctsl^tm1Cptr/Ctsl^tm1Cptr
• Genetic Background: NOD.129P2-Ctsl^tm1Cptr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:153355 )

• sialadenitis is observed in both diabetic and nondiabetic mice at 6 months of age, however, number of lesions observed is less than number found in NOD mice (6.5 vs. 12-20)

decreased CD4-positive, alpha-beta T cell number ( J:153355 )

• number of CD4+ T cells is 3-fold reduced in thymus and lymph nodes as compared to NOD control

increased regulatory T cell number ( J:153355 )

• homozygotes exhibit a 2-fold increase in Foxp3-expressing T cells in comparison to heterozygotes

decreased susceptibility to autoimmune diabetes ( J:153355 )

• mice exhibit a complete resistance to diabetes

• adoptive transfer of GITR^hi-depleted Treg cells into NOD-Prkdc^scid host results in a diabetes incidence of 45.5%

endocrine/exocrine glands

salivary gland inflammation ( J:153355 )

• sialadenitis is observed in both diabetic and nondiabetic mice at 6 months of age, however, number of lesions observed is less than number found in NOD mice (6.5 vs. 12-20)

digestive/alimentary system

salivary gland inflammation ( J:153355 )

• sialadenitis is observed in both diabetic and nondiabetic mice at 6 months of age, however, number of lesions observed is less than number found in NOD mice (6.5 vs. 12-20)

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:153355 )

• number of CD4+ T cells is 3-fold reduced in thymus and lymph nodes as compared to NOD control

increased regulatory T cell number ( J:153355 )

• homozygotes exhibit a 2-fold increase in Foxp3-expressing T cells in comparison to heterozygotes